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Multiple granulocytic sarcoma associated with essential thrombocythemia

Yacouba Lazare Diallo, Marc Bernard, Patrick Tas, Thierry Lamy


Evolution of Essential Thrombocytemia (ET) to granulocytic sarcoma is a rare event. Here we report a case of multiple granulocytic sarcomas occurring twelve months after diagnosis of ET.

A 57 year old woman was diagnosed with ET at the haematology department of Rennes University Hospital.  She was treated with hydroxyurea , and following poor response she was switched to pipobroman and then anagrelide which were both stopped because of  intolerance.

Twelve months later, the patient presented with osteolysis and a diagnosis of acute megakaryoblastic leukemia (AML7) was made with CD34, CD31, EMA (epithelial membrane antigen), lysozym, factor VIII and myeloperoxidase (MPO) positive cells.  A partial remission (leukocyte and platelets counts normalized) was obtained after induction with cytarabin and idarubicin. The patient died five months later due to lung infection following salvage chemotherapy.

In conclusion, granulocytic sarcoma associated with ET is a very rare event. Bone lysis is an unusual presentation. The prognosis is unfavorable since disease is chemorefractory.


Granulocytic sarcoma, thrombocytemia, acute leukemia

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میز اداری صندلی مدیریتی صندلی اداری تبلیغات کلیکی میز تلویزیون پاراگلایدر آگهی رایگان محسن چاوشی مسیح و آرش آهنگ جدید دانلود آهنگ جدید خرید اینترنتی عکس بازیگران اطفار عکس بازیگران