Table 3: Toxicity of treatment in both arms
|
Toxicity |
(Gem-Ox) (12 cases) |
(Gem-Ox-Pem) (16 cases) |
P Value |
|
|
Hematological toxicity (grade
III & IV) |
||||
|
|
Anemia |
1 (8.3%) |
2 (12.5%) |
0.44 |
|
neutropenia |
3 (25%) |
5 (31.3%) |
0.31 |
|
|
Febrile
neutropenia |
1 (8.3%) |
1 (6.3%) |
0.51 |
|
|
thrombocytopenia |
2 (16.7%) |
3 (18.8%) |
0.37 |
|
|
GIT toxicity
(grade III & IV) |
||||
|
|
Nausea/vomiting |
3 (25%) |
7 (43.8%) |
0.19 |
|
diarrhea |
1 (8.3%) |
4 (25%) |
0.22 |
|
|
mucositis |
1 (8.3%) |
6 (37.5%) |
0.08 |
|
|
Neurotoxicity |
||||
|
|
Grade
II |
3 (25%) |
7 (43.8%) |
0.19 |
|
Grade
III |
2 (16.7%) |
4 (25%) |
0.32 |
|
|
Fatigue |
3 (25%) |
7 (43.8%) |
0.19 |
|
|
Skin rash |
1 (8.3%) |
4 (25%) |
0.22 |
|
|
Alopecia |
1 (8.3%) |
2 (12.5%) |
0.44 |
|
|
Elevated liver enzymes |
2 (16.7%) |
3 (18.8%) |
0.38 |
|
|
Hypertension |
1 (8.3%) |
2 (12.5%) |
0.44 |
|
Gem, gemcitabine ; Ox, oxaliplatin; Pem, pemetrexed