Table 1. Literature reporting granulocytic sarcoma complicating Essential Thrombocythemia
Authors |
Age sex |
Delay before SG transformation |
ET treatment |
Locations |
Immunohistochemistry |
AML |
SG Traitement |
SG evolution |
Au WY 2000 4 |
55/F |
84 months |
Melphalan, hydroxyurea |
left parietal bone |
CD31, CD34 |
AML |
UK |
UK |
Famoso G 2006 5 |
68/M |
60 months |
Hydroxyurea |
Muscle, left hip |
CD43, CD45, CD34, factor VIII, CD 117, Vimentin, EMA, CD68 |
AML7 |
Aracytin low dose |
1 month, death by pneumopathy |
Tanaka Y 2006 8 |
59/F* |
204 months |
Hydroxyurea, busulfan, mitobronitol, ranimustine |
Left hip, skin, liver and spleen |
CD13, CD33, CD34, CD117 |
AML2 |
Imatinib, aracytin and etoposide |
7 months, death by pneumopathy |
Shikata H 2009 7 |
72/M |
72 months |
Hydroxyurea |
Stomach, lung and spleen |
CD13, HLA-DR, CD34, CD117 |
AML |
UK |
5 months, death by pneumopathy |
Desplechin A, 2010 6 |
80/M** |
72 months |
Pipobroman, Anti platelet agregation |
Left hip |
UK |
AML7 |
UK |
4 months, evolution UK |
Our case 2011 |
57/F |
12 months |
Hydroxyurea pipobroman, anagrelide |
Sternum, mandible, femur |
CD34, CD31, EMA, MPO, lysozyme, factor VIII. |
AML7 |
Aracytin, idarubicine, etopisde, and mitoxantrone-aracytine |
5 months, death by pneumopathy |
* : Secondary fibrosis; ** : Jak 2 mutation. Abbreviations: MPO, myeloperoxydase; UK, unknown.