Table 1. Literature reporting granulocytic sarcoma complicating Essential Thrombocythemia

 

Authors

Age

sex

Delay before SG transformation

ET treatment

Locations

Immunohistochemistry

AML

SG  Traitement

SG evolution

Au WY      2000 4

55/F

84 months

Melphalan, hydroxyurea

left parietal bone

CD31, CD34

AML

UK

UK

Famoso G  2006 5

68/M

60 months

Hydroxyurea

Muscle, left hip

CD43, CD45, CD34, factor VIII, CD 117, Vimentin,  EMA, CD68

AML7

Aracytin low dose

1 month, death by pneumopathy

Tanaka Y  2006 8

59/F*

204 months

Hydroxyurea, busulfan, mitobronitol, ranimustine

Left hip, skin, liver and spleen

CD13, CD33, CD34, CD117

AML2

Imatinib, aracytin and etoposide

7 months, death by pneumopathy

Shikata H  2009 7

72/M

72 months

Hydroxyurea

Stomach, lung and spleen

CD13, HLA-DR, CD34, CD117

AML

UK

5 months, death by pneumopathy

Desplechin A, 2010 6

80/M**

72 months

Pipobroman, Anti platelet agregation

Left hip

UK

AML7

UK

4 months, evolution UK

Our case   2011

57/F

12 months

Hydroxyurea pipobroman, anagrelide

Sternum,  mandible, femur

CD34, CD31, EMA,  MPO, lysozyme, factor VIII.

AML7

Aracytin, idarubicine, etopisde, and mitoxantrone-aracytine

5 months, death by pneumopathy

 

* : Secondary fibrosis; ** : Jak 2 mutation. Abbreviations:  MPO, myeloperoxydase;  UK, unknown.